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Premature Ovarian Failure: Causes and Treatments

Dr. Seema Jain - Infertility Specialist & Gynecologist at CheQKmate Fertility|Maternity|Gynecology - Pimple Saudagar, PCMC
Dr. Seema Jain - Infertility Specialist & Gynecologist at CheQKmate Fertility|Maternity|Gynecology - Pimple Saudagar, PCMC
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Shivani 097Shivani 097
08:03 01 Jul 25
From the very beginning of our journey , the entire team has shown exceptional dedication, compassion, and expertise. Dr. Seema Jain ma’am is truly the best doctor I have ever met—extremely knowledgeable, understanding, and the most soft-spoken , who always made me feel comfortable and hopeful.Dr. Navneet ma'am and Dr. Ashwini ma'am were equally supportive and attentive, providing thorough guidance and encouragement at every step. Their teamwork and professionalism created an environment of trust and positivity throughout .I'm currently four months pregnant .I highly recommend this amazing team to anyone seeking fertility treatment—you will be in the best hands.
Divya AgarwalDivya Agarwal
03:31 01 Jul 25
My pregnancy journey so far (Ongoing 2nd Trimester) has been a mixture of emotions — Fear,Joy, anxiety, anticipation, and growth with some hiccups as I had miscarriage from my 1st pregnancy which was supported by Dr.Seema Jain to be mentally ready post reviewing the scan results.We were bit skeptical about making few decisions about the fertility treatment, However Dr.Seema Ma'am made sure we are well informed and clear about the alternative path to conceive .Later within couple of months I was able to conceive under guidance of Doctor. My appointments have been timely and informative.I appreciate clear communication and guidance during each month of my pregnancy journey so far.Ultrasound and lab test processes were smooth and efficient and reports were discussed and if there were any red flags it was addressed by Dr. Whenever we contacted the medical staff/Assistant Doctor we got the required support in our crucial/Emergency situation.Since its time for Pre natal Yoga,I had enrolled in further assistance which covered Topics like Prenatal yoga, Mental well being,Types of Delivery, Garbhasanskar, labor preparation, breastfeeding, and newborn care were covered well.I feel supported in managing pregnancy-related discomforts (Vomiting, nausea, etc.). as Doctor is available to address the queries.I am being guided well on supplements, and red flags to watch for.I'm thankful for the journey so far and hoping for a safe and smooth delivery.
Sneha GhoshSneha Ghosh
15:25 23 Jun 25
Choosing Cloudnine Hospital was one of the most important and emotional decisions of our lives—and we are so grateful we did. From the very first consultation, the entire team showed exceptional compassion, professionalism, and expertise.Dr Seema Jain took the time to thoroughly explain every step of the process and never made us feel rushed or uninformed. We appreciated their honesty, their evidence-based approach, and their constant encouragement through what can be a very challenging journey.The nursing staff and support team were equally amazing—always available to answer questions, offer reassurance, and celebrate small milestones with us. The clinic was clean, well-organised, and ran efficiently, but still felt personal and warm.Thanks to the care and dedication of the team at Cloudnine Hospital and we couldn’t be more thankful.
Surmit ShirvanSurmit Shirvan
09:14 23 Jun 25
I was taking treatment from Dr Seema Jain as was not able to conceive naturally. Due to her treatment and guidance was able to conceive and currently in my second trimester for pregnancy. Thanks for your guidance and support. Will be delivering the baby under her guidance as we trust her in this journey!!!!
Mahima rajMahima raj
06:22 21 Jun 25
We started consulting Dr. Seema Jain for ART treatment in 2024 since we had trouble conceiving. Considering we had crossed 34 years of age and our medical reports, she had suggested to proceed directly for IVF rather than trying other simpler treatments first. We were a bit concerned about directly starting IVF treatments but we decided to follow her advice. It took a few attempts, but we were finally able to successfully conceive in the third attempt. Over all these attempts, Dr. Seema ensured to modify the course of treatment after each attempt to maximize our chance of conception. Looking back now, we are glad we decided to follow her initial advice. Throughout our journey over the past year, Dr. Seema & her team have been readily available to address our concerns and queries. We sincerely recommend Dr. Seema Jain for your journey to parenthood.
mahesh khosemahesh khose
17:32 15 Jun 25
Very nice treatment, I recommend you to Dr Seema Jain.
Jayashree DhikaleJayashree Dhikale
05:50 14 Jun 25
Our journey to becoming parents began in 2021, and honestly, for a long time we wanted to believe it would be a straight shot, after each trial. After trying on our own for a bit, we explored options like a laparoscopy and IUI. When those didn't help, in late 2023, IVF became our next big step under Dr. Seema Jain.Our first embryo transfer didn't go well, which was a huge blow. We dusted ourselves off and tried again, and our second transfer actually resulted in a pregnancy, but heartbreakingly, the numbers weren't quite right, meaning another loss. Then, the third transfer also failed, leaving us feeling pretty worn out and wondering if this was even going to happen for us.Through all those tough moments, our fertility team was supportive. They were so good about explaining everything, no matter how many questions we threw at them. Their medical team's knowledge and genuinely caring approach really helped us make sense of all the complicated stuff and get through those incredibly difficult decisions.After those initial struggles, we went through another egg retrieval, and thankfully, we ended up with six healthy embryos. We decided to hit pause for a while, which was probably the best decision we made. That break gave us time to recharge emotionally and mentally. When we felt ready, we went for our very first frozen embryo transfer, and to our absolute disbelief and joy, it worked!This whole experience taught us so much about not giving up! Our strongest takeaway message for any couple fertility treatments is this: stand strong together, believe in your own journey, and remember that with the right guidance, everything is possible. Trusting your instincts, when things are tough, is just as vital as the medical treatments themselves. We're incredibly thankful to Dr. Seema Jain and her entire team who stood by us all the time.
garvita sharmagarvita sharma
14:11 05 Jun 25
radhika Moreradhika More
04:20 05 Jun 25
Sadhya SinghSadhya Singh
18:58 30 May 25
My journey to motherhood was a long one—two years filled with ups and downs, uncertainty, and emotional moments. But throughout this challenging time, Dr. Seema Jain was a constant source of hope and positivity 💫.What truly stood out about her was her unwavering optimism. Even when treatments didn’t work or we faced setbacks, she never gave up on me. She never used negative words or made me feel like I was the problem. Instead, she always said, “We will try again.” That hope she gave me, time and again, is something I will never forget 🌈.Today, I am blessed with a healthy baby boy 👶🏻, conceived naturally—and I truly believe it was possible because of the treatments and guidance I received from her. It was her careful approach, her encouragement, and her belief in me that made this miracle happen 💖.Another remarkable aspect of my experience was the incredible support from the entire office staff. They were always warm, well-organized, and attentive, ensuring that every visit was smooth and stress-free. It’s truly rare to come across a doctor whose dedication is so perfectly matched by a team that shares the same compassion and professionalism 🙌🏼.I am deeply grateful to Dr. Seema Jain—not just for her medical expertise, but for her compassion, patience, and positivitythroughout my entire journey. She is not just a doctor; she is a true blessing for anyone hoping to become a parent 🙏🏼✨.
Arti KumariArti Kumari
17:01 28 Sep 23
We had been trying for baby for quite sometime and then we consulted Seema Jain ma’am. Post consultation with her, we got positive result within 6 months. She didn’t enforce any unnecessary treatment or procedure, just with basic medication and few treatment, I got positive result. The consultation process throughout my pregnancy was very smooth, got proper guidance and prescriptions at every step. Her whole team is very professional, and assisted us very nicely. Thanks to her and whole team.
Dipanwita TapikarDipanwita Tapikar
13:19 27 Sep 23
It was the best experience with Dr.Seema Jain.She understands your problem and issues and then opts for the treatment. We are in contact with Dr. Seema Jain since 2021. With her guidance and support we conceived in our first try but had to terminate the pregnancy due to some issues. But she never lost hope and again we gave a fresh start and this time we conceived again and that too blessed with twins. The journey still was a bit difficult for us but still Dr. Seema Jain made sure that everything goes smoothly for us. In the last trimester, Due to high BP doctor advised us to go for a c-section in 36 weeks. Me and my husband were a bit nervous but again she as a super women made everything easy for us and under her guidance we delivered a baby girl and baby boy. Thank you so much Doctor for the support and guidance.
Dhanashree PhadkeDhanashree Phadke
10:27 17 Sep 23
Had just googled Dr. Seema Jain mam's name and visited her. She calmly listened to all our queries and answered them patiently.Mine was a high risk pregnancy so seema mam took extra care, she does not prescribe a long list of medicines and gives you lot of confidence in the whole pregnancy journey. She quickly responds to emails in case of any queries.A special mention to the clinic staff as well...very polite and warm staff. The whole process in the clinic is very smooth and hassle-free.
Sumit MahismareSumit Mahismare
12:51 15 Sep 23
Consulted Dr. Seema Jain Madam since 1st Month and I must say she is best Gynecologist. Very caring, kind, down to earth and she understand her parents very well and time to time motivate too.Whenever I visit, I always got positive vibes. The way she explains things was awesome. She is definitely a best gynecologist as well as very supportive and friendly.Dr. Seema Jain Madam has really been so great that the whole pregnancy journey with her and the delivery days in the hospital have been a piece of cake - seamless with absolute-zero difficulties.
Bhagyashree PatangeBhagyashree Patange
09:45 07 Sep 23
We consulted Dr. Seema Jain when we were planning for a baby. After the +ve pregnancy test there was a minor risk. The doctor handled it with a lot of diligence due to which our twin pregnancy stayed secured. Our pregnancy and delivery experience has been good. Delivery happened at a premature stage but in the right way and the right time. Both my babies are healthy and growing beautifully.We would highly recommend Dr. Seema Jain for a safe and secure journey to parenthood. Indeed the best gynaec in Pune!
Rinku SangleRinku Sangle
18:01 17 Aug 23
Dr. Seema is one of the best gynecologist in city. She is a woman of less words but a lot of positivity and full of energy. Her work speaks for her knowledge and experience.  Best part is she never prescribed unnecessary medicines and treatments until it's really required. Much thanks to Seema M'am for the normal delivery without any complications. I would recommend expecting mothers to be under her guidance and enjoy this experience.
Shweta SinghShweta Singh
20:18 13 May 23
I have been a patient of Dr. Seema since 2020. I randomly had gone to get my ovaries health checked before planning for a baby and to my surprise I found that i wasn't ovulating regularly. Dr Seema patiently explained me the root cause of it with solution. She started with some guidance than jumping onto medicines directly. After some relief from covid chaos I went to her again with negative pregnancy test and that's when she suggested me to start with some low dozed medications. Due to her expertise and faith I kept on moving along with her plan patiently and one day finally saw two pink lines on the test kit. When I showed her that kit she was immensely happy for us. I trust her with treatment and support. She has always been kind to me and kept encouraging me to embrace my pregnancy journey. Another important factor is she pushes for normal delivery...which is great. Not to forget her staff has always been supportive and helpful. Always smiling and greeting you. Few months back we were blessed with a baby boy. I am thankful to Dr. Seema Jain for giving us the chance to become happy parents to our child. Lots of love to you ma'am. 🥰🥰
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Table of Contents

Women facing irregular cycles or fertility concerns should consider consulting a trusted Gynecologist at Pimple Saudagar for personalized care and treatment

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Introduction to Premature Ovarian Failure

Premature Ovarian Failure (POF), also called Primary Ovarian Insufficiency (POI), happens when the ovaries stop functioning properly before a woman reaches the age of 40. It leads to menstrual irregularities, infertility, and symptoms linked to low estrogen. Beyond its medical impact, POF can cause deep emotional strain for women and couples longing for children. The expertise of a trusted Gynecologist at Pimple Saudagar like Dr. Seema Jain can bring clarity and hope by offering both medical and emotional guidance.

Understanding the Ovarian Function

Ovaries regulate fertility and hormonal health by:

  • Releasing mature eggs for potential conception
  • Producing estrogen and progesterone, which regulate the menstrual cycle and support other body functions

In POF, these processes slow down or stop prematurely, resulting in challenges that affect fertility and overall wellness. Consulting a reliable Gynecologist at Pimple Saudagar can make a critical difference by enabling early diagnosis and intervention.

Know More About-

Egg Health & Ovarian Reserve By Dr. Seema Jain IVF Specialist in Pimple Saudagar

Causes of Premature Ovarian Failure

POF develops from multiple underlying causes rather than one single reason. The contributing factors range from genetics to lifestyle and medical treatments.

Common Causes:

  • Genetic abnormalities such as Turner syndrome or Fragile X premutation
  • Autoimmune responses where the immune system targets ovarian tissues
  • Cancer therapies including chemotherapy and pelvic radiation
  • Viral infections damaging ovarian tissue
  • Idiopathic causes which remain unexplained in many cases

Cause

Mechanism

Approximate Percentage

Genetic abnormalities

Chromosomal defects altering ovarian reserve

20%

Autoimmune disorders

Self-targeted immune attack on follicles

10–20%

Cancer treatments

Chemotherapy or pelvic radiation

30%

Infections

Viral or bacterial involvement

<5%

Idiopathic

Unknown cause

50%

 

Symptoms and Diagnosis

Key Symptoms:

  • Missed or irregular menstrual cycles
  • Hot flashes and disturbed sleep
  • Vaginal dryness and discomfort during intercourse
  • Loss of libido
  • Difficulty achieving pregnancy

Diagnostic Steps:

  1. Hormonal blood tests: FSH and estradiol levels provide clarity
  2. Genetic testing: Detects inherited abnormalities
  3. Ultrasound scans: To check follicle count and ovarian size

Women noticing these symptoms should reach out to a Gynecologist at Pimple Saudagar promptly to avoid delays in care.

Treatment Options for Premature Ovarian Failure

Though there is no definitive cure for POF, several therapies help manage symptoms and improve fertility chances.

  1. Hormone Replacement Therapy (HRT)
  • Restores estrogen and progesterone levels
  • Reduces risks linked to osteoporosis and heart disease
  1. Fertility Solutions
  • IVF with donor eggs, offering the highest success rate
  • Egg freezing for women identified early with ovarian compromise
  1. Supportive Treatments
  • Vaginal estrogen for dryness
  • Psychological counseling to handle emotional stress
  1. Advanced Therapies (Emerging)
  • Platelet-rich plasma (PRP) to stimulate ovarian function
  • Stem-cell–based approaches under study

Couples should explore these treatments under the guidance of an experienced Gynecologist at Pimple Saudagar such as Dr. Seema Jain, who helps personalize the treatment pathway.

Lifestyle and Supportive Care

Holistic care improves wellbeing and complements medical therapies.

Recommendations:

  • Include calcium-rich foods and vitamin D in the diet
  • Engage in strength training and regular exercise
  • Practice yoga and meditation to ease stress
  • Avoid smoking and excessive alcohol

When combined with treatment from a skilled Gynecologist at Pimple Saudagar, these steps strengthen both physical and emotional resilience.

Data Insights: Incidence and Outcomes

Factor

Data

Women affected globally

1% below age 40

IVF success with donor eggs

40–60% per cycle

Fracture risk without HRT

4 times higher

Emotional impact

70% report anxiety or depression

These figures underline the need for timely consultation with a Gynecologist at Pimple Saudagar to manage health and fertility effectively.

FAQs Most Frequent Asked Questions

Yes, early detection is possible with advanced tools like Anti-Müllerian Hormone (AMH) levels, Follicle Stimulating Hormone (FSH) checks, and detailed genetic panels. These tests help identify women at risk even before symptoms become obvious. Consulting a Gynecologist at Pimple Saudagar ensures these investigations are interpreted correctly, helping women plan fertility strategies proactively.

While POF mainly stems from genetic or autoimmune factors, lifestyle influences like poor diet, obesity, and chronic stress can worsen hormonal imbalance. Oxidative stress and insulin resistance are known to impact ovarian function further. A Gynecologist at Pimple Saudagar can combine lifestyle guidance with medical care to improve health outcomes.

Low estrogen associated with POF accelerates bone loss, raising the risk of osteoporosis and fractures. It also disrupts cardiovascular protection normally offered by estrogen, increasing the risk of heart conditions. Regular monitoring and hormone replacement under a Gynecologist at Pimple Saudagar can protect long-term bone and heart health.

Beyond donor eggs, women can explore ovarian tissue cryopreservation, experimental PRP treatments, and stem-cell–based approaches. While still evolving, these methods offer hope for women looking for alternatives. A Gynecologist at Pimple Saudagar like Dr. Seema Jain can guide patients through available and emerging options.

Yes, some women with POF may still have occasional ovulation, making spontaneous conception possible, though rare. It is important to track cycles and work closely with a Gynecologist at Pimple Saudagar to optimize these opportunities. Even when natural conception does not occur, timely intervention maximizes fertility chances.

Why Patients Choose Dr. Seema Jain

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About Dr. Seema Jain

Dr. Seema Jain is a compassionate and highly skilled Gynecologist at Pimple Saudagar. As an expert in reproductive medicine, she has guided many women and couples through the challenges of infertility and conditions like Premature Ovarian Failure. Her approach blends advanced medical technologies with genuine patient care. Known as a trusted Gynecologist at Pimple Saudagar, she offers both clinical expertise and emotional support. With her experience, countless families have found hope and confidence on their journey toward parenthood.

Patients consistently choose Dr. Seema Jain as their fertility doctor in Pimplle Saudagar for several compelling reasons that set her apart from other specialists. Her approach combines clinical expertise with genuine compassion, creating an experience that addresses both medical and emotional aspects of fertility treatment.

  • Exceptional Success Rates and Patient Satisfaction
  • Personalized Care and Attentive Approach
  • Comprehensive Treatment Philosophy
  • Avoiding Unnecessary Interventions
  • Emotional Support Throughout the Journey

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