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When Fertility Has No Clear Answers: Understanding Unexplained Infertility

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Insights from Dr. Seema Jain – Fertility Specialist at Ravet

Fertility Specialist at Ravet

What Is Unexplained Infertility?

You’ve been trying. You’ve followed every possible instruction. All tests come back normal. Still, pregnancy doesn’t happen. This is what doctors often call unexplained infertility.

It’s not a comforting label. It offers no clear answers, no pinpointed reason. But it’s a diagnosis that roughly 10-15% of infertile couples receive, even after standard fertility evaluations. It doesn’t mean nothing is wrong. It only means the cause hasn’t yet been found with current testing tools. And that’s exactly why expertise matters.

When you meet an experienced Fertility Specialist at Ravet, like Dr. Seema Jain, the approach shifts from simply treating test results to truly understanding the couple’s biology, lifestyle, and timing at a deeper level.

Why Does It Happen Despite “Normal” Reports?

Let’s understand this better. Most basic fertility tests include:

  • Hormonal Blood Tests
  • Ultrasounds To Track Ovulation
  • Semen Analysis
  • Avoiding Unnecessary Interventions
  • Fallopian Tube Testing (usually via HSG)

Now, if all of these look fine, but conception hasn’t happened in over a year (or six months if the woman is over 35), the term “unexplained infertility” is used. But many underlying issues can still be missed. These might include:

  • Subtle Sperm Functional Defects Are Not Visible in a Standard Semen Report
  • Low-Grade Endometriosis That Doesn’t Show Up on Scans
  • Immune Incompatibility Between Partners
  • Molecular Implantation Issues in the Uterus
  • Poor Egg-Sperm Binding, Even When Both Appear Healthy on Paper
  • A Seasoned Fertility Specialist at Ravet Can Often Identify Patterns or Clues That Routine Screening Misses.

What Tests Might Still Be Missing?

Advanced tests can shed more light on cases labelled “unexplained.” Some of these include:

  • Sperm DNA Fragmentation Index (DFI): Evaluates hidden sperm DNA damage
  • Laparoscopy: Checks for Minor Pelvic Pathologies or Early-Stage Endometriosis
  • Endometrial Receptivity Analysis (ERA): Assesses the timing and health of the uterine lining for implantation
  • Autoimmune profile: To rule out subtle immune-related embryo rejection
  • AMH and Antral Follicle Count: Gives a more detailed picture of ovarian reserve

At her clinic, Dr. Seema Jain, renowned Fertility Specialist at Ravet, takes a step-by-step, tailored approach, ensuring that no stone is left unturned in diagnosing the real cause behind infertility.

When Should You See a Fertility Specialist at Ravet?

If you’re under 35 and have been trying for over a year—or over 35 and trying for more than six months—it’s wise to consult a Fertility Specialist at Ravet. If your reports show no issues and pregnancy still hasn’t happened, don’t wait for time to complicate the situation further.

Early consultation means timely interventions. And sometimes, it just takes a new set of trained eyes—like those of Dr. Seema Jain—to spot what others may have missed.

What Are the Best Treatment Options?

Once unexplained infertility is diagnosed, your treatment plan will depend on age, duration of trying, and previous responses to medications. Here are common evidence-backed approaches:

  • Lifestyle Correction: Addressing Stress, Weight, and Sleep for Both Partners
  • Ovulation Induction + Timed Intercourse: Enhancing Egg Release While Advising on Exact Timing
  • IUI (Intrauterine Insemination): Especially Helpful When Subtle Sperm or Cervical Issues Are Suspected
  • IVF (In Vitro Fertilization): Controls Fertilization, Selects the Best Embryos, Bypasses Many Hidden Issues
  • ICSI: Used in IVF to Inject a Single Sperm into the Egg, Helpful If Sperm Function Is Suspected
  • Embryo Freezing + PGT: Ensures Chromosomally Normal Embryos Are Used

Couples under Dr. Seema Jain’s care often say her clarity, confidence, and calm explanations take away half the stress before treatment even begins.

FAQs About Unexplained Infertility

 It’s real, but it’s also a limitation of current testing. As of now, many micro-level issues (like immune interactions, endometrial receptivity, molecular sperm-egg signals) are not tested routinely. With more advanced diagnostics, a cause is often eventually found.

Generally, after 3–6 cycles of timed intercourse or IUI without success—especially if the woman is over 35—IVF is recommended. IVF not only increases chances but can also reveal insights during the process (such as egg maturity or fertilization behavior).

Yes. Chronic stress can impact hormone release, egg quality, ovulation, sperm function, and even uterine receptivity. In many cases, reducing stress along with mild medical support has resulted in successful conception.

 Yes. Many couples conceive naturally even after being diagnosed with unexplained infertility. However, with increasing age, natural chances reduce significantly—so time-sensitive treatment planning is crucial.

 A lot. With over 30 years of experience, Dr. Seema Jain, leading Fertility Specialist at Ravet, focuses on the ‘why behind the why.’ Her experience with subtle patterns, customized tests, and no-copy-paste protocols means your treatment is never guesswork—it’s guided by clinical wisdom.

About Dr. Seema Jain – Fertility Specialist at Ravet

Play Video about Fertility Specialist at Ravet

Dr. Seema Jain, a senior Fertility Specialist at Ravet, brings over three decades of clinical excellence to her practice. Known for her sharp clinical acumen, realistic planning, and gentle patient approach, she specializes in unexplained infertility, complex cases, and high-precision fertility treatments like IVF and ICSI.

She works alongside a team of expert embryologists and counselors to provide holistic, accurate, and ethical fertility care. For those who feel confused or frustrated by “normal” reports and “no results,” Dr. Seema Jain offers insight, support, and real outcomes. Struggling with unclear reasons behind infertility? Book your consultation with Dr. Seema Jain, a trusted Fertility Specialist at Ravet, and begin your journey toward clarity and conception.

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Dr. Seema Jain - Infertility Specialist and Gynecologist - CheQKmate, IVF | Fertility | Gynecology
Dr. Seema Jain - Infertility Specialist and Gynecologist - CheQKmate, IVF | Fertility | Gynecology
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Shivani 097Shivani 097
08:03 01 Jul 25
From the very beginning of our journey , the entire team has shown exceptional dedication, compassion, and expertise. Dr. Seema Jain ma’am is truly the best doctor I have ever met—extremely knowledgeable, understanding, and the most soft-spoken , who always made me feel comfortable and hopeful.Dr. Navneet ma'am and Dr. Ashwini ma'am were equally supportive and attentive, providing thorough guidance and encouragement at every step. Their teamwork and professionalism created an environment of trust and positivity throughout .I'm currently four months pregnant .I highly recommend this amazing team to anyone seeking fertility treatment—you will be in the best hands.
Divya AgarwalDivya Agarwal
03:31 01 Jul 25
My pregnancy journey so far (Ongoing 2nd Trimester) has been a mixture of emotions — Fear,Joy, anxiety, anticipation, and growth with some hiccups as I had miscarriage from my 1st pregnancy which was supported by Dr.Seema Jain to be mentally ready post reviewing the scan results.We were bit skeptical about making few decisions about the fertility treatment, However Dr.Seema Ma'am made sure we are well informed and clear about the alternative path to conceive .Later within couple of months I was able to conceive under guidance of Doctor. My appointments have been timely and informative.I appreciate clear communication and guidance during each month of my pregnancy journey so far.Ultrasound and lab test processes were smooth and efficient and reports were discussed and if there were any red flags it was addressed by Dr. Whenever we contacted the medical staff/Assistant Doctor we got the required support in our crucial/Emergency situation.Since its time for Pre natal Yoga,I had enrolled in further assistance which covered Topics like Prenatal yoga, Mental well being,Types of Delivery, Garbhasanskar, labor preparation, breastfeeding, and newborn care were covered well.I feel supported in managing pregnancy-related discomforts (Vomiting, nausea, etc.). as Doctor is available to address the queries.I am being guided well on supplements, and red flags to watch for.I'm thankful for the journey so far and hoping for a safe and smooth delivery.
Sneha GhoshSneha Ghosh
15:25 23 Jun 25
Choosing Cloudnine Hospital was one of the most important and emotional decisions of our lives—and we are so grateful we did. From the very first consultation, the entire team showed exceptional compassion, professionalism, and expertise.Dr Seema Jain took the time to thoroughly explain every step of the process and never made us feel rushed or uninformed. We appreciated their honesty, their evidence-based approach, and their constant encouragement through what can be a very challenging journey.The nursing staff and support team were equally amazing—always available to answer questions, offer reassurance, and celebrate small milestones with us. The clinic was clean, well-organised, and ran efficiently, but still felt personal and warm.Thanks to the care and dedication of the team at Cloudnine Hospital and we couldn’t be more thankful.
Surmit ShirvanSurmit Shirvan
09:14 23 Jun 25
I was taking treatment from Dr Seema Jain as was not able to conceive naturally. Due to her treatment and guidance was able to conceive and currently in my second trimester for pregnancy. Thanks for your guidance and support. Will be delivering the baby under her guidance as we trust her in this journey!!!!
Mahima rajMahima raj
06:22 21 Jun 25
We started consulting Dr. Seema Jain for ART treatment in 2024 since we had trouble conceiving. Considering we had crossed 34 years of age and our medical reports, she had suggested to proceed directly for IVF rather than trying other simpler treatments first. We were a bit concerned about directly starting IVF treatments but we decided to follow her advice. It took a few attempts, but we were finally able to successfully conceive in the third attempt. Over all these attempts, Dr. Seema ensured to modify the course of treatment after each attempt to maximize our chance of conception. Looking back now, we are glad we decided to follow her initial advice. Throughout our journey over the past year, Dr. Seema & her team have been readily available to address our concerns and queries. We sincerely recommend Dr. Seema Jain for your journey to parenthood.
mahesh khosemahesh khose
17:32 15 Jun 25
Very nice treatment, I recommend you to Dr Seema Jain.
Jayashree DhikaleJayashree Dhikale
05:50 14 Jun 25
Our journey to becoming parents began in 2021, and honestly, for a long time we wanted to believe it would be a straight shot, after each trial. After trying on our own for a bit, we explored options like a laparoscopy and IUI. When those didn't help, in late 2023, IVF became our next big step under Dr. Seema Jain.Our first embryo transfer didn't go well, which was a huge blow. We dusted ourselves off and tried again, and our second transfer actually resulted in a pregnancy, but heartbreakingly, the numbers weren't quite right, meaning another loss. Then, the third transfer also failed, leaving us feeling pretty worn out and wondering if this was even going to happen for us.Through all those tough moments, our fertility team was supportive. They were so good about explaining everything, no matter how many questions we threw at them. Their medical team's knowledge and genuinely caring approach really helped us make sense of all the complicated stuff and get through those incredibly difficult decisions.After those initial struggles, we went through another egg retrieval, and thankfully, we ended up with six healthy embryos. We decided to hit pause for a while, which was probably the best decision we made. That break gave us time to recharge emotionally and mentally. When we felt ready, we went for our very first frozen embryo transfer, and to our absolute disbelief and joy, it worked!This whole experience taught us so much about not giving up! Our strongest takeaway message for any couple fertility treatments is this: stand strong together, believe in your own journey, and remember that with the right guidance, everything is possible. Trusting your instincts, when things are tough, is just as vital as the medical treatments themselves. We're incredibly thankful to Dr. Seema Jain and her entire team who stood by us all the time.
garvita sharmagarvita sharma
14:11 05 Jun 25
radhika Moreradhika More
04:20 05 Jun 25
Sadhya SinghSadhya Singh
18:58 30 May 25
My journey to motherhood was a long one—two years filled with ups and downs, uncertainty, and emotional moments. But throughout this challenging time, Dr. Seema Jain was a constant source of hope and positivity 💫.What truly stood out about her was her unwavering optimism. Even when treatments didn’t work or we faced setbacks, she never gave up on me. She never used negative words or made me feel like I was the problem. Instead, she always said, “We will try again.” That hope she gave me, time and again, is something I will never forget 🌈.Today, I am blessed with a healthy baby boy 👶🏻, conceived naturally—and I truly believe it was possible because of the treatments and guidance I received from her. It was her careful approach, her encouragement, and her belief in me that made this miracle happen 💖.Another remarkable aspect of my experience was the incredible support from the entire office staff. They were always warm, well-organized, and attentive, ensuring that every visit was smooth and stress-free. It’s truly rare to come across a doctor whose dedication is so perfectly matched by a team that shares the same compassion and professionalism 🙌🏼.I am deeply grateful to Dr. Seema Jain—not just for her medical expertise, but for her compassion, patience, and positivitythroughout my entire journey. She is not just a doctor; she is a true blessing for anyone hoping to become a parent 🙏🏼✨.
Arti KumariArti Kumari
17:01 28 Sep 23
We had been trying for baby for quite sometime and then we consulted Seema Jain ma’am. Post consultation with her, we got positive result within 6 months. She didn’t enforce any unnecessary treatment or procedure, just with basic medication and few treatment, I got positive result. The consultation process throughout my pregnancy was very smooth, got proper guidance and prescriptions at every step. Her whole team is very professional, and assisted us very nicely. Thanks to her and whole team.
Dipanwita TapikarDipanwita Tapikar
13:19 27 Sep 23
It was the best experience with Dr.Seema Jain.She understands your problem and issues and then opts for the treatment. We are in contact with Dr. Seema Jain since 2021. With her guidance and support we conceived in our first try but had to terminate the pregnancy due to some issues. But she never lost hope and again we gave a fresh start and this time we conceived again and that too blessed with twins. The journey still was a bit difficult for us but still Dr. Seema Jain made sure that everything goes smoothly for us. In the last trimester, Due to high BP doctor advised us to go for a c-section in 36 weeks. Me and my husband were a bit nervous but again she as a super women made everything easy for us and under her guidance we delivered a baby girl and baby boy. Thank you so much Doctor for the support and guidance.
Dhanashree PhadkeDhanashree Phadke
10:27 17 Sep 23
Had just googled Dr. Seema Jain mam's name and visited her. She calmly listened to all our queries and answered them patiently.Mine was a high risk pregnancy so seema mam took extra care, she does not prescribe a long list of medicines and gives you lot of confidence in the whole pregnancy journey. She quickly responds to emails in case of any queries.A special mention to the clinic staff as well...very polite and warm staff. The whole process in the clinic is very smooth and hassle-free.
Sumit MahismareSumit Mahismare
12:51 15 Sep 23
Consulted Dr. Seema Jain Madam since 1st Month and I must say she is best Gynecologist. Very caring, kind, down to earth and she understand her parents very well and time to time motivate too.Whenever I visit, I always got positive vibes. The way she explains things was awesome. She is definitely a best gynecologist as well as very supportive and friendly.Dr. Seema Jain Madam has really been so great that the whole pregnancy journey with her and the delivery days in the hospital have been a piece of cake - seamless with absolute-zero difficulties.
Bhagyashree PatangeBhagyashree Patange
09:45 07 Sep 23
We consulted Dr. Seema Jain when we were planning for a baby. After the +ve pregnancy test there was a minor risk. The doctor handled it with a lot of diligence due to which our twin pregnancy stayed secured. Our pregnancy and delivery experience has been good. Delivery happened at a premature stage but in the right way and the right time. Both my babies are healthy and growing beautifully.We would highly recommend Dr. Seema Jain for a safe and secure journey to parenthood. Indeed the best gynaec in Pune!
Rinku SangleRinku Sangle
18:01 17 Aug 23
Dr. Seema is one of the best gynecologist in city. She is a woman of less words but a lot of positivity and full of energy. Her work speaks for her knowledge and experience.  Best part is she never prescribed unnecessary medicines and treatments until it's really required. Much thanks to Seema M'am for the normal delivery without any complications. I would recommend expecting mothers to be under her guidance and enjoy this experience.
Shweta SinghShweta Singh
20:18 13 May 23
I have been a patient of Dr. Seema since 2020. I randomly had gone to get my ovaries health checked before planning for a baby and to my surprise I found that i wasn't ovulating regularly. Dr Seema patiently explained me the root cause of it with solution. She started with some guidance than jumping onto medicines directly. After some relief from covid chaos I went to her again with negative pregnancy test and that's when she suggested me to start with some low dozed medications. Due to her expertise and faith I kept on moving along with her plan patiently and one day finally saw two pink lines on the test kit. When I showed her that kit she was immensely happy for us. I trust her with treatment and support. She has always been kind to me and kept encouraging me to embrace my pregnancy journey. Another important factor is she pushes for normal delivery...which is great. Not to forget her staff has always been supportive and helpful. Always smiling and greeting you. Few months back we were blessed with a baby boy. I am thankful to Dr. Seema Jain for giving us the chance to become happy parents to our child. Lots of love to you ma'am. 🥰🥰
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